It wasn't long before Rubens and his fellow artists, such as Jacques Jordaens, started using the house as a backdrop for their paintings. Even Rubens's pupil, Anthony van Dyck, was heavily impressed by his master's feeling for design. Rubens painted a portrait of his wife, Isabella Brant, in front of the portico. The fact she is laughing is no coincidence. Isabella and Peter Paul were very happy in the home they bought together. She ran a well-oiled household of three children, while Rubens was in charge of the most well-known painter's studio in Europe.
Following the death of his daughter, Clara Serena, and of his wife, Isabella, life in the house became a lot quieter. Rubens felt alone and seemed to take refuge in his job as a foreign diplomat. A few years later, life in the house became livelier again, thanks to Helena Fourment, who was 37 years younger than Rubens. Rubens married her and they had five children together. Life on the Wapper square was buzzing with activity once more and the house was a home again.